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TriMix

TriMix is a compounded medication that is used to treat erectile dysfunction. It is a mixture of papaverine, phentolamine, and alprostadil, which act as vasodilators. This means they widen blood vessels to allow more blood flow to the penis.

What is TriMix?

  • TriMix is a compounded medication that is used to treat erectile dysfunction. It is a mixture of papaverine, phentolamine, and alprostadil, which act as vasodilators. This means they widen blood vessels to allow more blood flow to the penis.
  • TriMix is a safe, fast-acting, long-lasting ED treatment option for men, especially those who have not had luck with other common medications like Viagra®.
  • TriMix is only available at compounding pharmacies like SandsRx and is made custom for each patient’s unique needs.

What Is Erectile Dysfunction (ED)?

The inability to achieve or maintain penile erection long enough for sexual activity. This condition affects men primarily between the ages of 40 and 70.

 

About 20 million men in the United States suffer from this condition, and this number is projected to increase to greater than 300 million by the year 2025[1]

 

The standard first-line treatment for this condition is oral phosphodiesterase type 5 (PDE5) inhibitors such as Sildenafil and Tadalafil; these work by relaxing of the corpus cavernosum inside the penis and consequently, penile erection [2]

 

Some individuals, however, who may not tolerate PDE5 inhibitors for any reason are poorly responsive to this class of medications. An alternative option that has been used with promising results in the management and treatment of ED is TriMix. TriMix is a second-line medication used to treat ED in men for whom PDE5 inhibitors are not an acceptable option.

Components of TriMix

TriMix ED injections contain a mixture of three drugs: phentolamine, papaverine and alprostadil.

 

This drug is not readily available in traditional retail pharmacies but must be specially made at compounding pharmacies like SandsRx. The components of TriMix work synergistically causing sustained penile erections in individuals suffering from ED.

 

In contrast to the first-line drug treatment of ED, PDE5 inhibitors, which are administered orally, TriMix ED treatment is an injectable medication that is administered locally into the penis.

 

This medication is typically compounded at dosages that are tailored to the requirements of everyone.

How does TriMix work?

Injecting Trimix into the corpus cavernosum, results in the relaxation, expansion, and filling of the corpus cavernosum with blood. This may result in penile erections that last throughout the duration of sexual intercourse.[3]

More About Trimix for ED Treatment

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  • Why Take TriMix For ED Treatment?
  • Side Effects of TriMix Injections
  • Who Should Not Take TriMix?
  • How To Store TriMix ED Injections
  • How to Self-Administer

Why Do Men Take TriMix For ED Treatment?

There are two primary reasons that men with ED may consider using TriMix ED injections:

  1. Failed treatment with first-line therapy such as PDE5 inhibitors.
  2. Hypersensitivity or other reactions to PDE5 inhibitors.
    Injectable TriMix has been shown to be efficacious in the management of ED. Studies have indicated that TriMix has an approximate overall success rate of 80 – 90 percent [4]

Side Effects of TriMix Injections

  1. Mild to moderate pain during injection
  2. Painful sensation with erection
  3. Small amount of bleeding at the injection site.
  4. Call your healthcare provider if you notice any redness, lumps, swelling, tenderness, or curvature of the erect penis. The prescribing physician should be consulted
  5. immediately if the erection becomes prolonged.

Who Should Not Take TriMix?

Do not take this medicine with any of the following Conditions:

  • Hypersensitivity or allergy to any component of this formulation.
  • Conditions predisposing you to priapism (painful erection lasting 4 hours or more)
  • Sickle cell anemia
  • Multiple myeloma or leukemia
  • Anatomical deformation of the penis or penile implants
  • Direction by your physician that sexual activity is inadvisable or contraindicated.

How To Store TriMix ED Injections

Store refrigerated or frozen as directed, protect from light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

How to Self-Administer

Some men may feel anxious or squeamish about self-injecting themselves, this is a relatively painless procedure if done properly with correct technique. Discussed below are the steps that are needed to safely self-administer the TriMix injection [5][6]

  • Wash hands thoroughly with soap and water or an alcohol-based solution to maintain proper hygiene.
  • Wipe the top of the rubber stopper thoroughly with an alcohol pad.
  • Insert a syringe into the vial through the rubber stopper and draw out the prescribed amount of TriMix into the syringe. Ensure that there are no air bubbles by tapping the syringe.
  • Find an injection site on the penis. Do not inject at the top or the bottom of the penis. Also avoid injecting directly into any visible veins or arteries on the penis, as well as along the midline. The optimal locations to administer the TriMix injection are at the sides of the penis. Avoid using the same spot repeatedly for injections as this may result in the scarring of penile tissue.
  • Once an injection site has been found, thoroughly wipe it with a fresh alcohol swab.
    Insert the needle into the penis and slowly depress the plunger to release the TriMix medication into the corpora cavernosa of the penis. Remove and carefully dispose of the syringe when this completed.
  • Apply pressure to the injection site and massage the penis to ensure thorough distribution of the medication throughout the tissues inside the penis.

 

The effects of TriMix ED injections become evident about 5 – 15 minutes after its injection into the penis as it induces a penile erection. Its duration action typically varies depending on the individual, ranging anywhere between half an hour to an hour. However, its effects should not last longer than 3 hours. The prescribing physician should be consulted immediately if the erection becomes prolonged.

Contact SandsRx Compounding Pharmacy For ED Treatment With TriMix

 

TriMix is an innovative treatment for erectile dysfunction that offers a safe, effective alternative to traditional ED treatments. SandsRx compounding pharmacy is proud to offer TriMix injections as an effective treatment option for our patients, and we can ensure personalized care from start to finish. We specialize in urology compounding and men’s health, and we have three locations in Wylie, Frisco, and McKinney, TX and we are very proud to be a trusted compounding pharmacy near Dallas and Fort Worth, TX. Contact us to begin the treatment process today.

Click Here for Trimix Injection Illustration Brochure

References

 

Montague DK, Jarow JP, Broderick GA, et al. Chapter 1: The management of erectile dysfunction: an AUA update. J Urol 2005;174:230-9.

Leungwattanakij S, Flynn V, Hellstrom WJG. Intracavernosal injection and intraurethral therapy for erectile dysfunction. Urol Clin North Am 2001;28:343-354.

Delcour, C., et al., The effect of papaverine on arterial and venous hemodynamics of erection. J Urol, 1987. 138(1): p. 187-9.

Mooradian, A.D., et al., Biweekly intracavernous administration of papaverine for erectile dysfunction. West J Med, 1989. 151(5): p. 515-7.

Dinsmore, W.W., Medical treatment of impotence with papaverine and phentolamine intracavernosal injection. Ulster Med J, 1990. 59(2): p. 174-6.

Keogh, E.J., et al., Treatment of impotence by intrapenile injections of papaverine and phenoxybenzamine: a double blind, controlled trial. Aust N Z J Med, 1989. 19(2): p. 108-12.

Kirkeby, H.J., et al., [Infusion cavernosography and erectile dysfunction]. Ugeskr Laeger, 1990. 152(24): p. 1724-6.