Progesterone is a naturally occurring hormone in the body that is synthesized in the ovaries, testes, placenta, and adrenal cortex. Progesterone is primarily used as a fertility medication or as part of HRT for women. Common uses in this field include treatment of amenorrhea, abnormal uterine bleeding, or as a contraceptive. It is also used to help prevent early pregnancy failure in women with corpus luteum insufficiency, including women undergoing assisted reproductive technology [9]. Progesterone is used for supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for women getting fertility treatment due to progesterone deficiency and for the treatment of secondary amenorrhea.

Progesterone injections are also used for the reduction of endometrial hyperplasia, and the attendant risk of endometrial carcinoma in postmenopausal women receiving hormone replacement therapy. It is also used as a treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathologies such as fibroids or uterine cancer.

Progesterone is a hormone that plays an important role in pregnancy and when there’s not enough progesterone in the body, women can experience symptoms such infertility issues or recumbent miscarriages. Sometimes during IVF treatment, the medication can interfere with the production of Progesterone in the body, which is where a supplement may be prescribed to re-balance hormone levels. At SandsRx, we offer progesterone injections as part of a personalized plan of fertility medication and care.

Progesterone injections are considered a safe treatment for HRT for women and fertility and are classified in FDA pregnancy category B. Several studies of women exposed to progesterone during pregnancy for luteal support have not demonstrated a significant increase in fetal malformations.

• Progesterone injections should only be used during early pregnancy under the observation of an ART specialist
• Progesterone should not be used if there is ectopic pregnancy, during cases of missed abortion, or during diagnostic tests for pregnancy.
• In high doses, injectable progesterone is an anti-fertility drug and may chemically induce female infertility.

In general, the American Academy of Pediatrics considers progesterone to be compatible with breast-feeding the presence of progestins in the milk are not expected to have adverse effects on lactation production. However, the effects of progestins present in breast milk on the nursing infant have not been determined. The administration of any medication to nursing mothers should consider the benefit of the drug to the mother and the potential for risk to the breast-fed infant.