Progesterone is a naturally occurring progestin. In the body, it is synthesized in the ovaries, testes, placenta, and adrenal cortex. Progesterone is primarily used to treat amenorrhea, abnormal uterine bleeding, or as a contraceptive. It is also used to help prevent early pregnancy failure in women with corpus luteum insufficiency, including women undergoing assisted reproductive technology 
Progesterone is indicated for supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea.
Progesterone is also used for the reduction of the incidence of endometrial hyperplasia, and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy. It is also used as a treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.
When you should not use Progesterone Injection
- If you are allergic to progesterone, progesterone-like drugs, benzyl alcohol.
- If you have unusual vaginal bleeding which has not been evaluated by your doctor.
- If you have liver disease.
- If you have known or suspected cancer of the breast or genital organs.
- If you have a miscarriage and your physician suspects some tissue is still in the uterus.
- If you have or have had blood clots in the legs, lungs, eyes, or elsewhere.
Risks of Progesterone Injection
Abnormal blood clotting. Blood clots have been reported with the use of estrogens and pregestational drugs (alone or in combination). Call your doctor immediately if you suspect you have this condition.
Be alert for unusual signs and symptoms. If any of these warning signals (or any other unusual symptoms) happen while you are using Progesterone Injection, call your doctor immediately:
- Abnormal bleeding from the vagina.
- Pains in the calves or chest, a sudden shortness of breath or coughing blood indicating possible clots in the legs, heart, or lungs.
- Severe headache or vomiting, dizziness, faintness, or changes in vision or speech, weakness or numbness of an arm or leg indicating possible clots in the brain or eye.
- Breast lumps, which could be associated with fibrocystic disorders, fibroadenoma, or breast cancer.
- Yellowing of the skin and/or white of the eyes indicating possible liver problem.
(Ask your doctor or health-care provider to show you how to examine your breasts monthly.)
Consult your doctor if you experience any of the side effects mentioned below, or other side effects.
- Breakthrough bleeding, spotting, changes in menstrual flow, amenorrhea
- Change in weight (increase or decrease)
- Pain, irritation, swelling, and/or redness at the injection area.
- General swelling
- Vaginal discharge
- Yellow discoloration of skin or white of eyes
- Breast tenderness, discharge from the nipple
- Skin reactions including rash, hives, itching, and swelling.
- Hair loss or growth of new hair
- Mental depression
- Insomnia or sleepiness
- Anaphylactoid (life-threatening allergic) reaction with symptoms that may include a sense of uneasiness or apprehension; flushing; fast, throbbing heartbeat; itching; hives; difficult breathing; swelling of the throat; fainting; nausea; vomiting; or convulsions.
*If you experience sleepiness, do not drive, or operate machinery.
Progesterone is classified in FDA pregnancy category B. In general, several studies of women exposed to progesterone during pregnancy for luteal support have not demonstrated a significant increase in fetal malformations.
- Progesterone should only be used during early pregnancy under the observation of an ART specialist
- Progesterone should not be used if there is ectopic pregnancy, during cases of missed abortion, or during diagnostic tests for pregnancy.
- In high doses, injectable progesterone is an anti-fertility drug and may chemically induce female infertility.
In general, the American Academy of Pediatrics considers progesterone to be compatible with breast-feeding the presence of progestins in the milk are not expected to have adverse effects on lactation production. However, the effects of progestins present in breast milk on the nursing infant have not been determined. The administration of any medication to nursing mothers should consider the benefit of the drug to the mother and the potential for risk to the breast-fed infant.
Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture, and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.
Pritts EA, Atwood AK. Luteal phase support in infertility treatment: a meta-analysis of the randomized trials. Hum Reprod 2002;17:2287-99