Leuprolide is a synthetic analog of naturally occurring gonadotropin-releasing hormone (GnRH). Leuprolide is generally indicated as a palliative treatment of advanced prostatic cancer.
It has also been known for years that Lupron (or other GnRH agonist medications) can stimulate an effective LH surge, which results in mature eggs release, to be retrieved for IVF procedure 
A new twist on the antagonist ovarian stimulation protocol for IVF called the “Lupron trigger protocol” or GnRH agonist trigger protocol has recently been used by some fertility specialists to eliminate the development of ovarian hyperstimulation syndrome, which could be caused by using the standard trigger shot, hCG injection .
Side Effects and Precautions
Common side effects include:
- Local discomfort
- Bruising and soreness at the injection site
- Ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort)
- Vaginal bleeding, pelvic pain, breast tenderness, hot flashes, vaginal dryness, constipation, headache, weakness, and dizziness
- There is potential for serious pulmonary conditions and thromboembolic events (difficulty breathing or chest tightness)
Warnings and Precautions
Contact the Physician immediately if the patient experiences any of the following:
- An allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue or face, or hives). Difficulty urinating, bone pain, numbness, tingling or weakness in the legs or arms.
- Symptoms of ovarian hyperstimulation syndrome (OHSS) (excessive fluid retention and severe abdominal discomfort) or symptoms of pulmonary conditions and thromboembolic events (difficulty breathing or chest tightness).
It is crucial that this dose be given EXACTLY at the date and time instructed by your physician. If you miss your scheduled dose you must immediately contact your physician for instructions.
- Hypersensitivity to GnRH, GnRH agonist or any of the excipients in LUPRON DEPOT
Category X -may cause fetal harm when administered to a pregnant woman.
Leuprolide is not indicated for use in nursing mothers. It is not known whether Leuprolide is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Leuprolide, a decision should be made to discontinue nursing or discontinue the drug considering the importance of the drug to the mother.
Store in a refrigerator, protect from light. Keep all medicine out of the reach of children. Throw away any unused medicine after the Beyond Use Date. Do not flush unused medications or pour down a sink or drain.
Castillo, J. C., Humaidan, P., & Bernabéu, R. (2014). Pharmaceutical options for triggering of final oocyte maturation in ART. BioMed research international, 2014, 580171. El Tokhy O, Kopeika J, El-Toukhy T. An update on the prevention of ovarian hyperstimulation syndrome. Womens Health (Lond). 2016;12(5):496-503. doi:10.1177/1745505716664743
Engmann, L.L., Maslow, B.S., Kaye, L.A. et al. Low dose human chorionic gonadotropin administration at the time of gonadotropin releasing-hormone agonist trigger versus 35 h later in women at high risk of developing ovarian hyperstimulation syndrome – a prospective randomized double-blind clinical trial. J Ovarian Res 12, 8 (2019).